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Kawasaki Disease
Kawasaki disease is an acute inflammation caused by an
infectious agent, possibly a virus, and named after the
Japanese pediatrician who first described it in 1967. The
disease typically affects children between three and four
years of age.
The major features of the disease are:
- fever (lasting as long as three weeks) with wide,
daily swings
- inflamed eyes and eyelids
- reddish (“strawberry”) tongue, lips, and throat
- swollen hands and feet with reddened palms and soles
and later peeling
- red rash on the trunk of the body
- enlarged lymph nodes in the neck
One of the complications of Kawasaki disease is damage to
the arteries from inflammation. Inflammation can weaken the
walls of the arteries and cause them to form tiny bulges
called aneurysms. If the coronary arteries are involved,
clots can form that prevent blood flow to the heart muscle
and can cause damage. Although only about 15 to 30 per cent
of children with Kawasaki disease develop this complication,
all children need to be evaluated by a cardiologist.
Treatment
Once Kawasaki disease is diagnosed, your child may be given
high dose IV gammaglobulin as it may reduce the risk of
coronary artery aneurysms. The standard treatment for all
children diagnosed with Kawasaki disease is daily aspirin
until your cardiologist is certain there are no aneurysms.
Aspirin is an antiinflammatory drug that also prevents blood
clots from forming in the coronary arteries.
Follow Up
A cardiac echocardiogram (ultrasound) may be done towards
the end of the acute phase of the illness and again during
the subacute and convalescent phases. Children with minor
cases may have the cardiac echo at about 1 to 2 months after
the acute illness has subsided and again one year later. If
no aneurysms are found, they are considered normal and no
further follow up is required.
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